Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reich, O; Regauer, S.
Hormonal therapy of endometrial stromal sarcoma.
Curr Opin Oncol. 2007; 19(4):347-352
Doi: 10.1097/CCO.0b013e3281a7ef3a
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Reich Olaf
- Co-Autor*innen der Med Uni Graz
- Regauer Sigrid
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- Abstract:
- PURPOSE OF REVIEW: Low-grade endometrial stromal sarcomas are steroid receptor positive tumors with slow tumor progression and high recurrence rates, which lack established treatment protocols. We present an update on hormonal therapy options. RECENT FINDINGS: In the past, hormonal therapy consisted of progestins for advanced/recurrent/metastatic low-grade endometrial stromal sarcomas. Aromatase inhibitors and gonadotropin-releasing hormone analogues have become new effective alternatives for first and second line treatment. The high recurrence rates after short disease free intervals in low-grade endometrial stromal sarcoma patients were partly due to inadvertent growth stimulation during estrogen-containing hormone replacement therapy and tamoxifen treatment, which - according to current knowledge - are contraindicated. Recently, hormonal therapy has been introduced for the prevention of recurrences. Aromatase inhibitors are becoming the treatment of choice, since progestins are poorly tolerated due to side effects. The effective duration of preventive hormonal therapy is still undetermined. SUMMARY: Hormonal therapy with progestins, aromatase inhibitors and gonadotropin-releasing hormone analogues has become an effective treatment alternative to radiation and chemotherapy for low-grade endometrial stromal sarcoma patients. Preventive hormonal therapy is of particular interest in the setting of concomitant endometriosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents, Hormonal - therapeutic use
- Aromatase Inhibitors - therapeutic use
- Endometrial Neoplasms - drug therapy
- Female - drug therapy
- Gonadotropin-Releasing Hormone - analogs and derivatives
- Goserelin - analogs and derivatives
- Humans - analogs and derivatives
- Neoplasm Recurrence, Local - analogs and derivatives
- Sarcoma, Endometrial Stromal - drug therapy
- Find related publications in this database (Keywords)
- aromatase inhibitors
- endometriosis
- gonadotropin releasing hormone analogues
- progestin