Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Ille, R; Spona, J; Zickl, M; Hofmann, P; Lahousen, T; Dittrich, N; Bertha, G; Hasiba, K; Mahnert, FA; Kapfhammer, HP.
Add-On-therapy with an individualized preparation consisting of free amino acids for patients with a major depression.
EUR ARCH PSYCHIAT CLIN NEUROS. 2007; 257(4): 222-229.
Doi: 10.1007/s00406-007-0711-9
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- Co-Autor*innen der Med Uni Graz
- Kapfhammer Hans-Peter
- Lahousen-Luxenberger Theresa
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- Abstract:
- The efficacy of a deficit oriented add-on therapy with free amino acids in depressive patients treated with the antidepressant Remeron was evaluated. About 40 in-patients were investigated by a randomised double-blind placebo-controlled study during 4 weeks. Plasma levels of 20 amino acids and measures of depression, suicidal behaviour and aggression were surveyed on admission and after a 4 weeks' therapy with Remeron plus an individualized amino acid mixture or placebo. The preparation of the amino acid mixture was based on an aminogram and consisted of essential amino acids plus vitamins and trace elements as co-factors for the amino acid metabolism. Patients of the experimental group showed a significantly better improvement of depression and a higher responder rate than those of the placebo group. The results suggest that oral application of a deficit oriented amino acid mixture can improve the therapeutic outcome of an antidepressant. Furthermore, lacking side effects of the amino acids resulting also in a better patient compliance may improve the benefit/risk ratio.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Amino Acids - blood
- Antidepressive Agents - adverse effects
- Depressive Disorder, Major - drug therapy
- Double-Blind Method - drug therapy
- Female - drug therapy
- Humans - drug therapy
- Male - drug therapy
- Middle Aged - drug therapy
- Psychiatric Status Rating Scales - drug therapy
- Self-Injurious Behavior - psychology
- Treatment Outcome - psychology
- Vitamins - therapeutic use
- Find related publications in this database (Keywords)
- major depression
- add-on-therapy
- aminogram
- individualized amino acid preparation