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Selected Publication:
Peris, K; Niedermeyer, H; Cerroni, L; Radaskiewicz, T; Chimenti, S; Höfler, H.
Detection of Epstein-Barr virus genome in primary cutaneous T and B cell lymphomas and pseudolymphomas.
Arch Dermatol Res. 1994; 286(7):364-368
Doi: 10.1007/BF00371794
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- Co-authors Med Uni Graz
- Cerroni Lorenzo
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- Abstract:
- The Epstein-Barr virus (EBV) genome has recently been identified in Hodgkin's disease (HD) and nodal non-Hodgkin's lymphomas (NHL). In order to elucidate the possible aetiopathogenetic role of EBV in benign and malignant lymphoproliferative disorders we investigated skin specimens from 24 patients with a primary cutaneous lymphoproliferative disorders (10 T-cell lymphomas 6 B-cell lymphomas and 8 pseudolymphomas) and from 22 normal individuals for the presence of EBV DNA using the polymerase chain reaction (PCR) technique and in situ hybridization (ISH) on formalin-fixed paraffin-embedded tissue sections. EBV DNA was identified by PCR in one of two cases of mycosis fungoides, in one of seven cases of pleomorphic T-cell lymphomas, in one case of centroblastic (CB) lymphoma of six B-cell lymphomas, and in three of eight pseudolymphomas. The EBV genome was also found in 2 of 22 specimens of normal skin. The small EBV-encoded nuclear RNAs, EBERs, were not detected in any PCR-positive sample by ISH. Based on our PCR and ISH findings, EBV does not seem to play a significant role in the development of cutaneous lymphomas.
- Find related publications in this database (using NLM MeSH Indexing)
- Base Sequence -
- Biopsy -
- DNA, Viral - analysis
- Genome, Viral - analysis
- Herpesvirus 4, Human - genetics
- Humans - genetics
- In Situ Hybridization - genetics
- Lymphoma, B-Cell - chemistry
- Lymphoma, Small Lymphocytic - chemistry
- Lymphoma, T-Cell, Cutaneous - chemistry
- Molecular Sequence Data - chemistry
- Polymerase Chain Reaction - chemistry
- Skin Neoplasms - chemistry
- Find related publications in this database (Keywords)
- Epstein-Barr Virus Genome
- Cutaneous Lymphomas
- Pseudolymphomas
- Polymerase Chain Reaction
- In Situ Hybridization