Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Cingolani, HE; Pérez, NG; Pieske, B; von Lewinski, D; Camilión de Hurtado, MC.
Stretch-elicited Na+/H+ exchanger activation: the autocrine/paracrine loop and its mechanical counterpart.
Cardiovasc Res. 2003; 57(4):953-960
Doi: 10.1016/S0008-6363(02)00768-X
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- Co-Autor*innen der Med Uni Graz
- Pieske Burkert Mathias
- von Lewinski Dirk
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- Abstract:
- The stretch of the cardiac muscle is immediately followed by an increase in the contraction strength after which occurs a slow force increase (SFR) that takes several minutes to fully develop. The SFR was detected in a wide variety of experimental preparations including isolated myocytes, papillary muscles and/or trabeculae, left ventricle strips of failing human myocardium, in vitro isovolumic and in vivo volume-loaded hearts. It was established that the initial increase in force is due to an increase in myofilament Ca2+ responsiveness, whereas the SFR results from an increase in the Ca2+ transient. However, the mechanism(s) for this increase in the Ca2+ transient has remained undefined until the proposal of Na+/H+ exchanger (NHE) activation by stretch. Studies in multicellular cardiac muscle preparations from cat, rabbit, rat and failing human heart have shown evidence that the stretch induces a rise in intracellular Na+ ([Na+]i) through NHE activation, which subsequently leads to an increase in Ca2+ transient via reverse-mode Na+/Ca2+ (NCX) exchange. These experimental data agree with a theoretical ionic model of cardiomyocytes that predicted an increased Na+ influx and a concurrent increase in Ca2+ entry through NCX as the cause of the SFR to muscle stretch. However, there are aspects that await definitive demonstration, and perhaps subjected to species-related differences like the possibility of an autocrine/paracrine loop involving angiotensin II and endothelin as the underlying mechanism for stretch-induced NHE activation leading to the rise in [Na+]i and reverse-mode NCX.
- Find related publications in this database (using NLM MeSH Indexing)
- Angiotensin II - physiology
- Animals - physiology
- Autocrine Communication - physiology
- Endothelins - physiology
- Humans - physiology
- Myocardial Contraction - physiology
- Paracrine Communication - physiology
- Sodium-Hydrogen Antiporter - physiology
- Find related publications in this database (Keywords)
- angiotensin
- endothelins
- Na/Ca-exchanger
- Na/H-exchanger
- stretch/m-e coupling