Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Regitnig, P; Ploner, F; Maderbacher, M; Lax, SF.
Bilateral carcinomas of the breast with local recurrence: analysis of genetic relationship of the tumors.
Mod Pathol. 2004; 17(5):597-602
Doi: 10.1038/modpathol.3800089
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- Führende Autor*innen der Med Uni Graz
- Regitnig Peter
- Co-Autor*innen der Med Uni Graz
- Ploner Ferdinand
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- Abstract:
- Local recurrence of bilateral breast carcinomas is rare, but of biological interest, since it is unclear as to which tumor the local recurrence is related to, the ipsilateral or the contralateral, or whether it is an independent neoplasm. The aim of this study was to investigate the genetic relationship of bilateral breast carcinomas to each other and to their local recurrences. Eight cases of bilateral breast carcinomas, five with and three without local recurrence were analyzed using a microsatellite assay for 13 microsatellite loci. The presence of loss of heterozygosity and microsatellite instability in the various tumors was used for clonal analysis. All eight bilateral breast carcinomas showed divergent alterations in at least two microsatellite loci, which ruled out a genetic relationship. Four of five local recurrences were genetically related to the ipsilateral tumor and unrelated to the contralateral tumor. Only one local recurrence that occurred 11.8 years after the surgery of an infiltrative lobular carcinoma simultaneously with distant metastases was genetically related to the contralateral breast carcinoma. Although the number of cases in our study is limited, there is evidence that local recurrence of bilateral breast carcinoma frequently arises from the ipsilateral tumor.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Breast Neoplasms - genetics
- Carcinoma, Ductal, Breast - genetics
- Carcinoma, Lobular - genetics
- DNA Mutational Analysis - genetics
- DNA, Neoplasm - chemistry
- Female - chemistry
- Humans - chemistry
- Immunohistochemistry - chemistry
- Loss of Heterozygosity - chemistry
- Microsatellite Repeats - chemistry
- Middle Aged - chemistry
- Neoplasm Recurrence, Local - genetics
- Receptor, erbB-2 - analysis
- Receptors, Estrogen - analysis
- Receptors, Progesterone - analysis
- Find related publications in this database (Keywords)
- bilateral breast carcinoma
- local recurrence
- microsatellite analysis
- loss of heterozygosity
- clonality