Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mangge, H; Schauenstein, K; Stroedter, L; Griesl, A; Maerz, W; Borkenstein, M.
Low grade inflammation in juvenile obesity and type 1 diabetes associated with early signs of atherosclerosis.
Exp Clin Endocrinol Diabetes. 2004; 112(7):378-382
Doi: 10.1055/s-2004-821023
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- Führende Autor*innen der Med Uni Graz
- Mangge Harald
- Co-Autor*innen der Med Uni Graz
- Borkenstein Helmuth Martin
- März Winfried
- Schauenstein Konrad
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- Abstract:
- Background: Subclinical inflammation has been implicated in the initiation and/or progression of atherosclerosis. Diabetes mellitus and obesity are risk factors for atherosclerosis, and asymptomatic low grade inflammation occurs prior to overt vascular lesions in these patients. In contrast to adults, little information exists concerning low grade inflammation in young type 1 diabetes and juvenile obesity. Aim: To investigate low grade inflammation and immune activation in juvenile diabetes mellitus and obesity. Methods: hs-CRP, soluble interleukin-2 receptor (sIL-2R), C-peptide, insulin, cortisol, vitamin 1312, folic acid, leptin, and homocysteine were determined in 148 patients with juvenile type 1 diabetes, 86 obese children and 142 normal weighted age-matched healthy controls. Intima-media thickness (IMT) and lumen diameter of both common carotid arteries (CCA) was measured by ultrasonography in 52 healthy pediatric controls, 10 diabetics, and 34 obese juveniles. Results: Serum hs-CRP was significantly elevated in patients with type 1 diabetes (p < 0.0001), and obese children (p < 0.0001) as compared to the control group. The obese juveniles (p < 0.0001) and the diabetics (p < 0.0001) showed significantly increased values for IMT of CAAs. Levels of homocysteine, sIL-2R, insulin, cortisol, vitamin 1312, and folic acid did not differ from the controls. The elevation of hs-CRP was more pronounced in obesity as compared to type 1 diabetes (p < 0.0001), and the hs-CRP values correlated significantly with body mass index standard deviation score (BMI-SDS) values. Furthermore, the IMT and the luminal diameter of CCAs showed significant correlations with BMI-SDS values. Conclusion: A low grade inflammation as determined by serum hs-CRP is significantly increased in children with type 1 diabetes, and even more pronounced in apparently healthy juveniles with obesity. The increased IMT of CCAs strongly argues for an association between this low grade inflammation and early atherosclerotic vessel injury.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Arteriosclerosis - etiology
- Body Mass Index -
- C-Peptide - blood
- C-Reactive Protein - analysis
- Carotid Artery, Common - pathology
- Child -
- Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - pathology
- Female -
- Folic Acid - blood
- Homocysteine - blood
- Humans -
- Inflammation - blood Inflammation - complications Inflammation - pathology
- Leptin - blood
- Male -
- Obesity - blood Obesity - complications Obesity - pathology
- Receptors, Interleukin-2 - blood
- Tunica Intima - pathology
- Vitamin B 12 - blood
- Find related publications in this database (Keywords)
- hs-CRP
- juvenile obesity
- juvenile type 1 diabetes