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SHR Neuro Cancer Cardio Lipid Metab Microb
McGovern, MM; Elles, R; Beretta, I; Somerville, MJ; Hoefler, G; Keinanen, M; Barton, D; Carson, N; Dequeker, E; Brdicka, R; Blazkova, A; Aymé, S; Schnieders, B; Muller, CR; Dalen, V; Martinez, AA; Kristoffersson, U; Ozguc, M; Mueller, H; Boone, J; Lubin, IM; Sequeiros, J; Taruscio, D; Williamson, B; Mainland, L; Yoshikura, H; Ronchi, E.
Report of an international survey of molecular genetic testing laboratories.
Community Genet. 2007; 10(3):123-131
Doi: 10.1159/000101753
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- Co-authors Med Uni Graz
- Höfler Gerald
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- Abstract:
- OBJECTIVE: To collect data on the practices of molecular genetic testing (MGT) laboratories for the development of national and international policies for quality assurance (QA). METHODS: A web-based survey of MGT laboratory directors (n = 827; response rate 63%) in 18 countries on 3 continents. QA and reporting indices were developed and calculated for each responding laboratory. RESULTS: Laboratory setting varied among and within countries, as did qualifications of the directors. Respondents in every country indicated that their laboratory receives specimens from outside their national borders (64%, n = 529). Pair-wise comparisons of the QA index revealed a significant association with the director having formal training in molecular genetics (p < 0.005), affiliation with a genetics unit (p = 0.003), accreditation of the laboratory (p < 0.005) and participation in proficiency testing (p < 0.005). Research labs had a lower mean report score compared to all other settings (p < 0.05) as did laboratories accessioning <150 samples per year. CONCLUSION: MGT is provided under widely varying conditions and regulatory frameworks. The data provided here may be a useful guide for policy action at both governmental and professional levels.
- Find related publications in this database (using NLM MeSH Indexing)
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- Find related publications in this database (Keywords)
- molecular genetic testing
- quality assurance
- genetic tests
- reporting
- proficiency testing
- genetics test regulation