Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Komericki, P; Grims, R; Kränke, B; Aberer, W.
Acute generalized exanthematous pustulosis from dalteparin.
J Am Acad Dermatol. 2007; 57(4): 718-721.
Doi: 10.1016/j.jaad.2007.05.025
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Komericki Peter
- Co-Autor*innen der Med Uni Graz
- Aberer Werner
- Grims Robert Hermann
- Kränke Birger
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- Abstract:
- Heparins are widely used for the prophylaxis and treatment of venous thromboembolism. Several types of immunologically mediated reactions to heparins are reported, among them delayed-type hypersensitivity reactions with erythematous, infiltrated itchy plaques at injection sites. We describe a female patient, whose localized reaction from dalteparin was followed by a generalized rash presenting as acute generalized exanthematous pustulosis. Subcutaneous provocation testing showed cross-reactions to enoxaparin, certoparin, reviparin, nadroparin, danaparoid, fondaparinux, but not to pentosan polysulfate. The danaparoid and in a lesser extent the nadroparin patch showed pustules. Within the next day, a generalized rash developed. The upper aspect of her trunk was highly affected and showed discrete pustules. Despite the fact that low molecular-weight heparins are widely prescribed, this is, to our knowledge, the first observation of a pustular drug eruption attributable to this class of substances.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Anticoagulants - administration and dosage
- Dalteparin - administration and dosage
- Drug Eruptions - administration and dosage
- Exanthema - chemically induced
- Female - chemically induced
- Humans - chemically induced
- Injections - chemically induced
- Middle Aged - chemically induced
- Skin Diseases, Papulosquamous - chemically induced
- Skin Tests - chemically induced
- Thrombophlebitis - drug therapy