Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kroll, H; Muntean, W; Kiefel, V; Giptner, A; Schlüter, C; Santoso, S; Mueller-Eckhardt, C.
Anti Ko(a) as a cause of neonatal alloimmune thrombocytopenia
Beitr Infusionsther Transfusionsmed. 1994; 32: 244-246.
PubMed
- Co-Autor*innen der Med Uni Graz
- Muntean Eugen
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- Abstract:
- Neonatal alloimmune thrombocytopenia (NAIT) is caused by maternal immunization against a paternal antigen on fetal platelets. The antigens mostly involved are Zwa (PlA1) and Br(a). The Ko alloantigen system which is localized on the N-terminal region of glycoprotein Ib usually causes antibody formation in polytransfused patients but is only rarely implicated in NAIT. Ko(a) antibodies raised in the mother of a thrombocytopenic newborn were shown to be detectable by platelet agglutination and MAIPA assay if the antigen-bearing N-terminal glycocalicin is protected from proteolytic degradation.
- Find related publications in this database (using NLM MeSH Indexing)
- Antigens, Human Platelet - immunology
- Blood Platelets - immunology
- Female - immunology
- Humans - immunology
- Infant, Newborn - immunology
- Isoantibodies - blood
- Male - blood
- Platelet Glycoprotein GPIb-IX Complex - immunology
- Pregnancy - immunology
- Purpura, Thrombocytopenic, Idiopathic - immunology