Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Pollheimer, VS; Bodo, K; Pollheimer, MJ; Zigeuner, R; Langner, C.
Merkel cell carcinoma metastasizing to the kidney mimicking primary neuroendocrine renal cancer.
APMIS. 2007; 115(6): 774-777.
Doi: 10.1111/j.1600-0463.2007.apm_617.x
(- Case Report)
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- Leading authors Med Uni Graz
- Langner Cord
- Co-authors Med Uni Graz
- Bodo Koppány Bonifác
- Pollheimer Marion
- Zigeuner Richard
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- Abstract:
- A 56-year-old male with a history of cutaneous neuroendocrine (Merkel cell) carcinoma presented with a solid mass of the left kidney, measuring 10 cm in largest diameter. On histology, the tumour was composed of loosely packed uniform cells with round-to-oval nuclei and scant cytoplasm. Immunohistochemically, the tumour cells diffusely expressed pancytokeratin and neuroendocrine markers, such as chromogranin A, synaptophysin and CD56 (NCAM). Distinct paranuclear dot-like expression of cytokeratin 20 showed the lesion to be metastatic Merkel cell carcinoma. This is the first reported case of Merkel cell carcinoma metastatic to the kidney mimicking primary neuroendocrine renal cancer. We discuss the differential diagnosis of the tumour and perform a systematic literature review, including potential indications for renal tumour biopsy in patients with a history of nonrenal malignancy.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Merkel Cell - classification
- Carcinoma, Neuroendocrine - pathology
- Humans - pathology
- Kidney Neoplasms - secondary
- Male - secondary
- Middle Aged - secondary
- Neoplasm Metastasis - secondary
- Find related publications in this database (Keywords)
- Merkel cell carcinoma
- carcinoma metastatic to the kidney
- neuroendocrine carcinoma of the kidney
- differential diagnosis