Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wolf, IH; Kodama, K; Cerroni, L; Kerl, H.
Nature of inflammatory infiltrate in superficial cutaneous malignancies during topical imiquimod treatment.
Am J Dermatopathol. 2007; 29(3):237-241
Doi: 10.1097/01.dad.0000211531.33670.94
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- Führende Autor*innen der Med Uni Graz
- Kerl Helmut
- Wolf Ingrid
- Co-Autor*innen der Med Uni Graz
- Cerroni Lorenzo
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- Abstract:
- Topical imiquimod (IQ) is an effective treatment for genital warts and various malignant tumors of the skin. IQ acts through the Toll-like receptor 7 leading to the production of cytokines and chemokines such as interferons, interleukins, and growth factors. We investigated the composition of the inflammatory cell infiltrate before, during, and after the treatment of 10 superficial cutaneous malignancies (melanoma in situ (n = 4), melanoma metastasis (n = 1), squamous cell carcinoma in situ (n = 4), and basal cell carcinoma (n = 1) with 5% IQ cream. Immunophenotyping revealed in all cases during treatment an increased population of T-lymphocytes positive for CD3, CD4 and CD8, as well as a considerable number of cytotoxic cells (TIA-1+, granzyme B+) and plasmacytoid dendritic cells (CD 123+). These findings further support previous investigations that the antitumor effects of IQ result from an enhanced cytotoxic T-cell mediated immune response and from the recruitment of plasmacytoid dendritic cells to the skin. The population of infiltrative inflammatory cells was similar in all patients irrespective of the type of tumor.
- Find related publications in this database (using NLM MeSH Indexing)
- Adjuvants, Immunologic - therapeutic use
- Aged -
- Aged, 80 and over -
- Aminoquinolines - therapeutic use
- Bowen's Disease - chemistry Bowen's Disease - drug therapy Bowen's Disease - pathology
- Carcinoma in Situ - chemistry Carcinoma in Situ - drug therapy Carcinoma in Situ - pathology
- Carcinoma, Basal Cell - drug therapy Carcinoma, Basal Cell - pathology
- Female -
- Humans -
- Hutchinson's Melanotic Freckle - chemistry Hutchinson's Melanotic Freckle - drug therapy Hutchinson's Melanotic Freckle - pathology
- Inflammation - chemically induced Inflammation - metabolism Inflammation - pathology
- Keratosis - drug therapy Keratosis - metabolism Keratosis - pathology
- Male -
- Melanoma - chemistry Melanoma - drug therapy Melanoma - pathology
- Middle Aged -
- Skin Neoplasms - chemistry Skin Neoplasms - drug therapy Skin Neoplasms - pathology
- Tumor Markers, Biological - analysis
- Find related publications in this database (Keywords)
- imiquimod
- immunohistology
- inflammatory cell infiltrate
- cytotoxic cells
- plasmacytoid dendritic cells
- superficial malignant tumors