Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Karakiewicz, PI; Trinh, QD; Bhojani, N; Bensalah, K; Salomon, L; de la Taille, A; Tostain, J; Cindolo, L; Altieri, V; Ficarra, V; Schips, L; Zigeuner, R; Mulders, PF; Valeri, A; Descotes, JL; Mejean, A; Patard, JJ.
Renal cell carcinoma with nodal metastases in the absence of distant metastatic disease: prognostic indicators of disease-specific survival.
EUR UROL. 2007; 51(6): 1616-1624.
Doi: 10.1016/j.eururo.2006.12.015
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-authors Med Uni Graz
- Hutterer Georg
- Schips Luigi
- Zigeuner Richard
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- OBJECTIVES: Outcome of patients with exclusive renal cell carcinoma (RCC) nodal metastases without distant metastases is not extensively described. We explored the ability of standard risk factors such as tumour size, Fuhrman grade, histologic subtype and symptom classification to predict renal cell carcinoma-specific survival (RCC-SS). METHODS: Analyses targeted 171 patients with RCC nodal metastases and absence of distant metastases. Univariable, multivariable, and predictive accuracy analyses addressed RCC-SS with the intent of identifying independent and most informative predictors of RCC-SS in this cohort of patients. RESULTS: Median RCC-SS was 2.3 yr. Symptom classification (61.3%, p<0.001) demonstrated the highest univariable accuracy. In multivariable analyses, symptom classification contributed the most to the combined predictive accuracy of all variables (+4.2%, p<0.001), followed by Fuhrman grade (+2.3%) and histologic subtype (+1.0%). CONCLUSIONS: Renal cell carcinoma-specific survival of patients with exclusive nodal metastases may show important variability. In presence of systemic symptoms, survival is extremely poor. Substantially better survival may be expected in patients with local or no symptoms. This observation has important implications when adjuvant therapies are considered.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma, Renal Cell - pathology
- Child - pathology
- Female - pathology
- Humans - pathology
- Kidney Neoplasms - pathology
- Lymphatic Metastasis - pathology
- Male - pathology
- Middle Aged - pathology
- Neoplasm Recurrence, Local - pathology
- Nephrectomy - methods
- Predictive Value of Tests - methods
- Prognosis - methods
- Proportional Hazards Models - methods
- Risk Factors - methods
- Survival Analysis - methods
- Find related publications in this database (Keywords)
- renal cell carcinoma
- symptom classification
- survival
- stage