Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Mlekusch, W; Lamprecht, M; Ottl, K; Tillian, M; Reibnegger, G.
A glucose-rich diet shortens longevity of mice.
MECH AGE DEV 1996 92: 43-51.
Doi: 10.1016%2FS0047-6374%2896%2901801-5
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- Co-Autor*innen der Med Uni Graz
- Öttl Karl
- Reibnegger Gilbert
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- Abstract:
- High plasma levels of glucose and insulin over long-time periods play an important role in the genesis of diabetic complications. There is evidence that the long term consumption of glucose-rich diet by rats is detrimental to insulin sensitivity. We investigated the effect of a glucose-rich diet on longevity of 70 female mice which were compared to 70 mice on a control diet. The average age of death of the control group was 568 +/- 139 days compared to 511 +/- 170 for the glucose group and the seven oldest mice of the control group died at age 890 +/- 52 days, while the seven oldest mice of the glucose group died at 833 +/- 49 days. These differences are statistically significant (P < or = 0.05). Our work shows that a life-long intake of a diet with 20% of total energy derived from glucose leads to a significant reduction of the average and maximal life-span in female mice and thus, supports previous observations of detrimental effects of high glucose intake over long periods.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Body Weight - drug effects
- Diet - drug effects
- Female - drug effects
- Glucose - pharmacology
- Longevity - drug effects
- Mice - drug effects
- Research Support, Non-U.S. Gov't - drug effects
- Find related publications in this database (Keywords)
- Female Mice
- Glucose Feeding
- Longevity