Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schmidt, EZ; Reininghaus, B; Enzinger, C; Ebner, C; Hofmann, P; Kapfhammer, HP.
Changes in brain metabolism after ECT-positron emission tomography in the assessment of changes in glucose metabolism subsequent to electroconvulsive therapy--lessons, limitations and future applications.
J Affect Disord. 2008; 106(1-2): 203-208.
Doi: 10.1016/j.jad.2007.06.009
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Reininghaus Eva
- Co-Autor*innen der Med Uni Graz
- Ebner Christoph
- Enzinger Christian
- Kapfhammer Hans-Peter
- Reininghaus Bernd
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: Electroconvulsive therapy (ECT) has been used as an effective treatment option in severe and treatment resistant cases of depression for decades. However the mode of action of ECT is still not fully understood. Advances in neuroimaging created new possibilities to understand the functional changes of the human brain. METHODS: Literature review of studies assessing possible changes in cerebral glucose metabolism pre- and post-ECT by PET, identified by PubMed. RESULTS: Studies were limited by small sample size, inhomogeneous study population with uni- and bipolar depressive patients and methodological inconsistencies. Despite considerable variance, reduction in glucose metabolism after ECT in bilateral anterior and posterior frontal areas represented the most consistent findings. CONCLUSIONS: Future research into this issue should include larger and more consistent cohorts of patients. Assessing clinical improvement of depression after ECT should allow to correlate changes in brain glucose metabolism with functional scores. Follow up PET scans after six or twelve months should be performed to test if changes in brain metabolism are persistent.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Glucose - metabolism
- Brain - radionuclide imaging
- Depressive Disorder - radionuclide imagingDepressive Disorder - therapy
- Dominance, Cerebral - physiology
- Electroconvulsive Therapy -
- Frontal Lobe - radionuclide imaging
- Humans -
- Positron-Emission Tomography -
- Find related publications in this database (Keywords)
- electroconvulsive therapy (ECT)
- depression
- positron emission tomography (PET)
- glucose metabolism