Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Nitsche, H; Nitsche, M; Sudi, K; Tschop, M; Zotter, H; Weinhand, G; Froehlich-Reiterer, E; Gallistl, S; Pirker, M; Borkenstein, M.
Ghrelin--an indicator for fat oxidation in obese children and adolescents during a weight reduction program.
J Pediatr Endocrinol Metab. 2007; 20(6):719-723
Doi: 10.1515/jpem.2007.20.6.719
Web of Science
PubMed
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FullText_MUG
- Leading authors Med Uni Graz
- Jasser-Nitsche Hildegard
- Co-authors Med Uni Graz
- Borkenstein Helmuth Martin
- Fröhlich-Reiterer Elke
- Gallistl Siegfried
- Nitsche-Resch Marianne
- Pirker Martina
- Zotter Heinz
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- Abstract:
- The aim of this study was to investigate the effect of short-term energy restriction combined with physical activity on changes in substrate oxidation and changes in plasma concentrations of ghrelin. We designed a longitudinal intervention study of 4.2 MJ (= 1,000 kcal) daily with exercise. Eighteen obese children and adolescents (age: 13.1 +/- 1.6 years, 13 girls, 5 boys, 17 White, 1 Black) participated. We measured body mass index (BMI), plasma ghrelin, resting energy expenditure (REE), VCO2, VO2 and respiratory quotient (RQ) at baseline and after 10 days. There was a significant decrease of BMI during the 10 day program (28.6 +/- 4.3 vs 27.5 +/- 4.2; p < 0.001). Ghrelin and RQ showed a tendency to increase, but the difference did not reach significance (ghrelin: 83.4 +/- 37.1 vs 99.5 +/- 41.2, p = 0067; RQ: 0.83 +/- 0.06 vs 0.85 +/- 0.08, p = 0.433). The changes in RQ were significantly and independently correlated with the changes in plasma ghrelin (p = 0.029). The increase in RQ suggests a shift from fat oxidation towards carbohydrate oxidation. Ghrelin reflects the same sensitivity as RQ to changes in energy balance. Therefore, ghrelin seems to be a sensitive indicator for changes in substrate oxidation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Biomarkers - blood
- Body Mass Index -
- Child -
- Dietary Fats - pharmacokinetics
- Energy Metabolism - physiology
- Female -
- Ghrelin -
- Humans -
- Longitudinal Studies -
- Male -
- Motor Activity -
- Obesity - blood
- Obesity - diet therapy
- Obesity - epidemiology
- Oxygen Consumption - physiology
- Peptide Hormones - blood
- Physical Fitness -
- Regression Analysis -
- Sensitivity and Specificity -
- Weight Loss - physiology
- Find related publications in this database (Keywords)
- ghrelin
- childhood obesity
- weight loss
- respiratory quotient
- fat oxidation
- physical activity