Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fruhwald, S; Herk, E; Hammer, HF; Holzer, P; Metzler, H.
Differential reversal of drug-induced small bowel paralysis by cerulein and neostigmine.
Intensive Care Med. 2004; 30(7):1414-1420
Doi: 10.1007/s00134-004-2317-2
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- Führende Autor*innen der Med Uni Graz
- Fruhwald Sonja
- Co-Autor*innen der Med Uni Graz
- Hammer Heinz
- Holzer Peter
- Metzler Helfried
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- Abstract:
- Objective: Cerulein and neostigmine are prokinetic drugs whose potency and effective dose range are barely known. The aim of this study was to assess their benefit for normal and compromised peristalsis. Design: In vitro, isolated segments of guinea pig small intestine. Setting: University laboratory. Interventions: Small bowel segments were mounted in tissue baths and luminally perfused with Tyrode solution. Test drugs (prokinetic: cerulein, neostigmine; inhibitory: atropine, hexamethonium, epinephrine, sufentanil) were added to the tissue bath. Measurements and results: Peristalsis was quantified via changes in the peristaltic pressure threshold. One-way and two-way analysis of variance (ANOVA) were used for statistical analysis. Cerulein (0.03-100 nM) stimulated normal peristalsis in a concentration-dependent manner and reversed paralysis of peristalsis induced by all inhibitory test drugs to a similar extent. The properistaltic effect of neostigmine was limited to a narrow concentration range (0.03-0.1 muM), whereas concentrations >0.3 muM inhibited peristalsis. Neostigmine more effectively counteracted blockage of peristalsis caused by atropine than that caused by hexamethonium. The inhibitory effects of epinephrine and sufentanil on peristalsis were reversed only at the concentration range of 0.1-0.3 muM neostigmine. Conclusions: Cerulein stimulates normal peristalsis in vitro at a wide concentration range and reverses blockage of peristalsis caused by drugs with a site of action either on the enteric nervous system or intestinal smooth muscle. Neostigmine's prokinetic effect, to the contrary, is limited to a small concentration range and best seen when peristalsis is depressed by blockage of cholinergic muscle activation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adjuvants, Anesthesia - pharmacology
- Adrenergic Agonists - pharmacology
- Animals -
- Atropine - pharmacology
- Ceruletide - pharmacology
- Dose-Response Relationship, Drug -
- Epinephrine - pharmacology
- Female -
- Ganglionic Blockers - pharmacology
- Guinea Pigs -
- Hexamethonium - pharmacology
- Intestine, Small - drug effects
- Male -
- Neostigmine - pharmacology
- Paralysis - chemically induced
- Parasympathomimetics - pharmacology
- Peristalsis - drug effects
- Sufentanil - pharmacology
- Find related publications in this database (Keywords)
- cerulein
- guinea pig
- intestinal motility
- neostigmine
- peristalsis
- prokinetic effect