Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Golaszewski, SM; Siedentopf, CM; Koppelstaetter, F; Rhomberg, P; Guendisch, GM; Schlager, A; Gallasch, E; Eisner, W; Felber, SR; Mottaghy, FM.
Modulatory effects on human sensorimotor cortex by whole-hand afferent electrical stimulation.
NEUROLOGY. 2004; 62(12): 2262-2269.
Doi: 10.1212/WNL.62.12.2262
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Gallasch Eugen
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- Abstract:
- OBJECTIVE: To investigate the effect of electrical stimulation of the nerve afferents of the hand on cortical activity elicited by whole-hand subthreshold stimulation for sensation in healthy human subjects. METHODS: Ten healthy volunteers were studied using BOLD-fMRI with 1) a test motor-task with finger-to-thumb tapping of the left hand, 2) a whole-hand afferent electrical stimulation of the left hand below the sensory level for sensation for 30 minutes, 3) a second fMRI run with the same paradigm as in the test motor-task immediately after electrical stimulation, and 4) a final identical fMRI run 2 hours post-stimulation to test the cortical changes induced by electrical stimulation. Experiments were carried out on a 1.5 T MR scanner and for fMRI echoplanar sequences were used. Data analysis was performed with SPM99. RESULTS: An increase of movement-related responses was seen within the primary motor and primary somatosensory areas of both hemispheres when comparing the test motor-task with the motor-task after electrical stimulation relative to the baseline or sham stimulation. Two hours post-stimulation the modulatory effects of mesh-glove stimulation diminished to baseline level except within the contralateral primary motor region. CONCLUSIONS: The increased BOLD response spatially localized within the sensorimotor cortex reflects an increase in neuronal activity that may provide augmented neuronal excitability.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
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- Hand - innervation
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- Neurons, Afferent - innervation