Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Holzheimer, RG; Capel, P; Cavaillon, JM; Cainzos, M; Frileux, P; Haupt, W; Marie, C; Müller, E; Ohmann, C; Schöffel, U; Lopez-Boado, MA; Sganga, G; Stefani, A; Kronberger, L.
Immunological surrogate parameters in a prognostic model for multi-organ failure and death.
Eur J Med Res. 2000; 5(7): 283-294.
PubMed
FullText
- Co-Autor*innen der Med Uni Graz
- Kronberger Leo
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Abstract:
- OBJECTIVE: To assess the ability of clinical or biochemical parameters to predict outcome (survival or non-survival; severe or moderate/no complication) using multiple regression analyses. DESIGN: Prospective, descriptive cohort study with no interventions SETTING: 12 surgical intensive care units of university hospitals and large community hospitals; four medical school research laboratories in eight European countries PATIENTS: 128 surgical patients with major intra-abdominal surgery admitted for at least two days to an intensive care unit MAIN OUTCOME MEASURES: Prediction of complications or survival based on analysis of clinical (Multiple Organ Dysfunction Score, Multi-Organ-Failure Score, Acute Physiology and Chronic Health Evaluation II scores) and immunological (plasma levels of endotoxin, endotoxin neutralizing capacity, IL-6, IL-8, cell associated IL-8, Fc-receptor polymorphism, soluble CD-14) parameters, with comparison of predicted and actual outcomes. RESULTS: APACHE II, MODS score, MOF score, platelets, IL-6, IL-8, ENC, cell ass. IL-8 were significantly different between survivors and non-survivors and patients with/without severe complications by univariate analysis. By multivariate analysis only MOF, MODS score, IL-6, platelets, comorbidity predicted complications with a sensitivity of 82% and a specificity of 87%. Multivariate analysis demonstrated that only APACHE II score, plasma IL-8 and complications predicted death (sensitivity 84%; specificity 90%). CONCLUSION: Immunological surrogate parameters may predict complications and death of surgical ICU patients. The use of several parameters may add to increase sensitivity and specificity in a prognostic model.
- Find related publications in this database (using NLM MeSH Indexing)
- APACHE -
- Anti-Bacterial Agents - administration and dosage
- Antigens, CD14 - blood
- Cohort Studies - blood
- Endotoxins - blood
- Humans - blood
- Interleukin-6 - blood
- Interleukin-8 - blood
- Models, Biological - blood
- Multiple Organ Failure - immunology
- Multivariate Analysis - immunology
- Outcome Assessment (Health Care) - immunology
- Prognosis - immunology
- Prospective Studies - immunology
- Receptors, Fc - blood