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Selected Publication:
Donnerer, J.
Depolarization-evoked release of glutamate, aspartate and gamma-aminobutyric acid from rat dorsal spinal cord slices does not originate from capsaicin-sensitive neurons.
Brain Res. 1991; 555(2):332-334
Doi: 10.1016%2F0006-8993%2891%2990360-8
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- Leading authors Med Uni Graz
- Donnerer Josef
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- Abstract:
- A release of endogenous glutamate (Glu), aspartate (Asp) and gamma-aminobutyric acid (GABA) from rat dorsal spinal cord slices was evoked by a 60 mM K(+)-depolarization (calcium dependent) and by 50 microM veratridine (tetrodotoxin sensitive) indicating a neuronal exocytosis mechanism. No release of the 3 amino acids investigated was obtained with the selective C-fiber excitant capsaicin (1 microM) and after impairment of afferent C-fibers the amount of amino acids released by K(+)-depolarization or veratridine was not reduced. These results suggest that amino acids may be exclusively transmitters of capsaicin-insensitive nerve structures in the rat dorsal spinal cord.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Aspartic Acid - metabolism
- Capsaicin - pharmacology
- Glutamates - metabolism
- Glutamic Acid - metabolism
- Immunohistochemistry - metabolism
- Neuromuscular Depolarizing Agents - pharmacology
- Neurons - drug effects
- Potassium - pharmacology
- Rats - pharmacology
- Rats, Inbred Strains - pharmacology
- Spinal Cord - metabolism
- Tetrodotoxin - pharmacology
- Veratridine - pharmacology
- gamma-Aminobutyric Acid - metabolism