Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Grims, RH; Weger, W; Reiter, H; Arbab, E; Kränke, B; Aberer, W.
Delayed-type hypersensitivity to low molecular weight heparins and heparinoids: cross-reactivity does not depend on molecular weight.
Br J Dermatol. 2007; 157(3): 514-517.
Doi: 10.1111/j.1365-2133.2007.08007.x
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Grims Robert Hermann
- Co-Autor*innen der Med Uni Graz
- Aberer Werner
- Arbab Emad
- Kränke Birger
- Weger Wolfgang
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- Abstract:
- BACKGROUND: Cross-reactivity is a widespread phenomenon in patients who develop cutaneous delayed-type hypersensitivity (DTH) reactions to low molecular weight heparins (LMWHs). As molecular weight is believed to be a key determinant of sensitization to heparins, the recently developed LMWH bemiparin, with the lowest molecular weight of all LMWHs, appeared to be a significant improvement. OBJECTIVES: To evaluate cross-reactivity between bemiparin and several other LMWHs and heparinoids by means of subcutaneous testing. Methods Test doses of bemiparin and several other LMWHs/heparinoids were given to eight patients with a history of local eczematous reactions after subcutaneous injection of enoxaparin. RESULTS: Seven of eight patients showed cross-reactivity following subcutaneous injection of bemiparin. In addition, nearly all tested substances caused local eczematous reactions in at least some patients, with the exception of fondaparinux, which was well tolerated by all patients. Of all substances tested, bemiparin had the highest cross-reactivity with enoxaparin. Substances with a lower molecular weight did not cross-react less frequently than the others. CONCLUSIONS: No significant correlation was found between the molecular weight of the tested substances and the frequency of DTH reactions. In patients with DTH to enoxaparin, the LMWH bemiparin is not a suitable alternative.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Anticoagulants - adverse effects
- Cross Reactions - immunology
- Drug Eruptions - etiology
- Female - etiology
- Heparin, Low-Molecular-Weight - administration and dosage
- Heparinoids - adverse effects
- Humans - adverse effects
- Hypersensitivity, Delayed - chemically induced
- Male - chemically induced
- Middle Aged - chemically induced
- Molecular Weight - chemically induced
- Skin Tests - chemically induced
- Find related publications in this database (Keywords)
- bemiparin
- cross-reactivity
- delayed-type
- hypersensitivity
- low molecular weight heparins
- molecular weight