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SHR Neuro Cancer Cardio Lipid Metab Microb

Sedlmayr, P.
Indoleamine 2,3-dioxygenase in materno-fetal interaction
CURR DRUG METAB. 2007; 8(3): 205-208. Doi: 10.2174/138920007780362491
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Leading authors Med Uni Graz: Sedlmayr Peter
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Abstract:: The mechanism of maternal immunotolerance of the semiallogeneic fetus has been a matter of intense investigation, The tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) is reported to be critically implicated. This article discusses findings pertaining to the role of IDO in pregnancy, its location at the feto-material interface, systemic induction of IDO in pregnancy and the association of IDO to spontaneous abortion and preeclampsia. Whereas there is a large body of evidence supporting the relevance of IDO as a key immunoregulatory factor in feto-maternal tolerance, open questions remain concerning as to its role.
Find related publications in this database (Keywords): feto-matemal tolerance; tryptophan catabolism; placenta; trophoblast; decidua; preeclampsia; spontaneous abortion