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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hofbauer, LC; Brueck, CC; Singh, SK; Dobnig, H.
Osteoporosis in patients with diabetes mellitus.
J Bone Miner Res. 2007; 22(9): 1317-1328.
Doi: 10.1359/jbmr.070510
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- Co-authors Med Uni Graz
- Dobnig Harald
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- Abstract:
- Demographic trends with longer life expectancy and a lifestyle characterized by low physical activity and high-energy food intake contribute to an increasing incidence of diabetes mellitus and osteoporosis. Diabetes mellitus is a risk factor for osteoporotic fractures. Patients with recent onset of type 1 diabetes mellitus may have impaired bone formation because of the absence of the anabolic effects of insulin and amylin, whereas in long-standing type 1 diabetes mellitus, vascular complications may account for low bone mass and increased fracture risk. Patients with type 2 diabetes mellitus display an increased fracture risk despite a higher BMD, which is mainly attributable to the increased risk of falling. Strategies to improve BMD and to prevent osteoporotic fractures in patients with type 1 diabetes mellitus may include optimal glycemic control and aggressive prevention and treatment of vascular complications. Patients with type 2 diabetes mellitus may additionally benefit from early visual assessment, regular exercise to improve muscle strength and balance, and specific measures for preventing falls.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Bone Density -
- Diabetes Mellitus, Type 1 - complications
- Diabetes Mellitus, Type 2 - complications
- Female - complications
- Humans - complications
- Male - complications
- Osteoporosis - complications
- Phenotype - complications
- Risk Factors - complications
- Find related publications in this database (Keywords)
- diabetes mellitus
- insulin
- osteoblasts
- osteoclast
- osteoporosis