Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Rutkowski, S; von Bueren, A; von Hoff, K; Hartmann, W; Shalaby, T; Deinlein, F; Warmuth-Metz, M; Soerensen, N; Emser, A; Bode, U; Mittler, U; Urban, C; Benesch, M; Kortmann, RD; Schlegel, PG; Kuehl, J; Pietsch, T; Grotzer, M.
Prognostic relevance of clinical and biological risk factors in childhood medulloblastoma: results of patients treated in the prospective multicenter trial HIT'91.
Clin Cancer Res. 2007; 13(9): 2651-2657.
Doi: 10.1158/1078-0432.CCR-06-1779
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- Co-Autor*innen der Med Uni Graz
- Benesch Martin
- Urban Ernst-Christian
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- Abstract:
- PURPOSE: To identify better risk stratification systems in childhood medulloblastoma based on clinical factors and analysis of routinely processed formalin-fixed tumor material. EXPERIMENTAL DESIGN: Formalin-fixed paraffin-embedded tumor samples from well-documented patients treated within the prospective randomized multicenter trial HIT'91 were analyzed for DNA amplification of c-myc and N-myc (n=133) and mRNA expression of c-myc and trkC (n=104; compared with human cerebellum) using validated methods of quantitative PCR and reverse transcription-PCR. Results were related to clinical data and outcome. RESULTS: TrkC and c-myc mRNA expression were identified as independent prognostic factors by multivariate analysis. Three risk groups were identified. (a) Favorable risk group: all 8 patients (2 metastatic) with high trkC (>1x human cerebellum) and low c-myc mRNA expression (
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Cerebellar Neoplasms - diagnosis
- Child - diagnosis
- Child, Preschool - diagnosis
- DNA, Neoplasm - analysis
- Female - analysis
- Humans - analysis
- Male - analysis
- Medulloblastoma - diagnosis
- Prospective Studies - diagnosis
- Proto-Oncogene Proteins c-myc - genetics
- RNA, Messenger - analysis
- Receptor, trkC - genetics
- Risk Factors - genetics
- Tumor Markers, Biological - analysis