Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Weber-Mzell, D; Urban, C; Benesch, M; Rojacher, T; Zois, B; Höfler, G; Schwinger, W.
Durable remission following a third allogeneic stem cell transplantation in a patient with repeatedly relapsing SAA. The importance of stroma cells for sustained engraftment?
Pediatr Transplant. 2007; 11(3):332-335
Doi: 10.1111/j.1399-3046.2006.00638.x
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Schwinger Wolfgang
- Sperl Daniela Ingrid
- Co-Autor*innen der Med Uni Graz
- Benesch Martin
- Höfler Gerald
- Urban Ernst-Christian
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- Abstract:
- Diagnosis of acquired AATP which finally progressed to SAA was established in an eight-yr-old boy. PBSCT from an HLA-identical unrelated donor using high numbers of CD34+ selected stem cells was performed and resulted in complete remission for almost two yr. However, SAA reoccurred with 100% donor hematopoiesis and was reversed by a second CD 34+ selected PBSCT from the same donor. Declining blood cell counts after an interval of two yr indicated second relapse. Chimerism analysis in PB and BM aspirates revealed a small autologous cell population of 4-12% and 2-11%, respectively. Finally, a third transplantation with unmanipulated BM from the same donor resulted in sustained remission with 100% donor hematopoiesis. The patient is in complete remission for more than five yr following the third SCT. Late graft failure or late graft rejection known to occur after transplantation of highly purified CD34+ cells, or even graft exhaustion caused by stromal dysfunction due to the underlying disease necessitated a third transplantation. Regardless of the cause of relapse, transplantation of unmanipulated BM instead of highly purified PBSCTs led to a permanent and stable engraftment in a third attempt after two previous PBSCTs.
- Find related publications in this database (using NLM MeSH Indexing)
- Anemia, Aplastic - immunology
- Antigens, CD34 - immunology
- Bone Marrow Transplantation - immunology
- Child - immunology
- Chimerism - immunology
- Hematopoietic Stem Cells - cytology
- Humans - cytology
- Male - cytology
- Mesenchymal Stem Cells - cytology
- Peripheral Blood Stem Cell Transplantation - cytology
- Remission Induction - cytology
- Stromal Cells - cytology
- Transplantation, Homologous - cytology
- Find related publications in this database (Keywords)
- severe aplastic anemia
- peripheral blood stem cell transplantation
- stroma cells