Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Linkesch, W; Luger, T; Kokoschka, EM.
Serum ferritin in patients with malignant melanoma
Acta Med Austriaca Suppl. 1979; 6(42): 346-349.
PubMed
- Führende Autor*innen der Med Uni Graz
- Linkesch Werner
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- Abstract:
- In 55 patients with malignant melanoma, in addition to hematologic parameters and blood chemistry, serumferritin was measured by a two-site IRMA-technique using a heterologous antibody system (Behringwerke). Tumor localisation was exactly classified due to a staging system (stage I--III). Elevation of serumferritin values in stage III was highly significant (p less than 0.0005) compared to stage I and II, as well as to normal controls (n = 60). There was no significant correlation between serumferritin and sedimentation rate, erythrocytes or serum iron. Only in stage III we found a significant negative correlation (p less than 0.05) between serumferritin and hemoglobin. Compared to normal controls, patients with stage III showed a significant decrease in serum-iron (p less than 0.01). A significant increase was found concerning serum-copper levels in all patients with melanoma. Though radioimmunometric methods now are not sensitive enough for the determination of tumor-specific isoferritins, serumferritin might be useful in detecting patients with malignant melanoma (stage III).
- Find related publications in this database (using NLM MeSH Indexing)
- Copper - blood
- Female - blood
- Ferritins - blood
- Humans - blood
- Iron - blood
- Male - blood
- Melanoma - blood
- Middle Aged - blood
- Neoplasm Staging - blood