Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Gaiger, A; Lion, T; Kalhs, P; Mitterbauer, G; Henn, T; Haas, O; Födinger, M; Kier, P; Forstinger, C; Quehenberger, P; Hinterberger, W; Jager, U; Linkesch, W; Mannhalter, C; Lechner, K.
Frequent detection of BCR-ABL specific mRNA in patients with chronic myeloid leukemia (CML) following allogeneic and syngeneic bone marrow transplantation (BMT).
LEUKEMIA. 1993; 7(11): 1766-1772.
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Linkesch Werner
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- Abstract:
- We performed a two-step polymerase chain reaction (PCR) to detect bcr-abl-specific mRNA in 440 peripheral blood and/or bone marrow samples of 30 chronic myeloid leukemia (CML) patients (mean 15, range 2-50 samples) following non T-cell-depleted allogeneic (n = 28) or syngeneic (n = 2) bone marrow transplantation (BMT). Median follow-up after BMT is 40 months (range 2-116 months), the median observation time 29 months (range 2-40 months). In 15 patients (50%), bcr-abl-specific mRNA could be detected following BMT. Bcr-abl positivity was rare in patients who were in hematological remission for at least 40 months (2/11). In five patients, PCR positivity was observed only once; all five patients are in complete hematological remission. Ten patients showed bcr-abl specific mRNA in two or more consecutive samples. Hematological relapse occurred in five of the latter patients. Bcr-abl positivity preceded hematological relapse in all cases. Bcr-abl positivity was detected more frequently in patients without graft-versus-host disease (GVHD) (11/15), than in patients with GVHD (4/15) (p < 0.02). Our data indicate that transient bcr-abl positivity is not usually followed by hematological relapse, while patients, who are positive in serial samples have a high risk of relapse.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Bone Marrow Transplantation -
- Female -
- Fusion Proteins, bcr-abl - genetics
- Graft vs Host Disease - genetics
- Humans - genetics
- Leukemia, Myeloid, Chronic - genetics
- Leukemia, Myeloid, Philadelphia-Positive - genetics
- Male - genetics
- Middle Aged - genetics
- Polymerase Chain Reaction - genetics
- RNA, Messenger - analysis
- RNA, Neoplasm - analysis
- Recurrence - analysis
- Transplantation, Homologous - analysis
- Transplantation, Isogeneic - analysis