Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Gisslinger, H; Gilly, B; Woloszczuk, W; Mayr, WR; Havelec, L; Linkesch, W; Weissel, M.
Thyroid autoimmunity and hypothyroidism during long-term treatment with recombinant interferon-alpha.
Clin Exp Immunol. 1992; 90(3):363-367
Doi: 10.1111/j.1365-2249.1992.tb05852.x
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- Co-Autor*innen der Med Uni Graz
- Linkesch Werner
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- Abstract:
- Forty-five patients with myeloproliferative or myelodysplastic syndromes, treated with recombinant interferon-alpha (rIFN-alpha) for a minimum of 1 up to 4 years, were examined for the occurrence of thyroid autoimmunity. During treatment, the rate of thyroid autoimmunity rose to more than 20%. The decrease in severity and frequency of thyroid autoimmunity after withdrawal of IFN shows that this is a potentially reversible side effect. The key determinant for the manifestation of this IFN-related autoimmune phenomenon seems to be a predisposition for autoimmunity, since patients with initially detectable thyroid antibodies are prone to exacerbations of thyroid autoimmunity. Concurrent with thyroid autoimmunity, hypothyroidism occurred but did not correlate with the levels of thyroid antibodies, although severe hypothyroidism in two patients was accompanied by increased levels of thyroid antibodies. This investigation shows that thyroid autoimmunity and consecutively hypothyroidism must be expected in certain patients treated with rIFN-alpha during long periods. Furthermore, it may be assumed that IFN-alpha does not induce the development of autoimmunity, but rather enhances the levels of pre-existent thyroid antibodies.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Autoimmunity -
- Biopterin - analogs and derivatives
- Female - analogs and derivatives
- Humans - analogs and derivatives
- Hypothyroidism - immunology
- Interferon Type I, Recombinant - administration and dosage
- Interferon Type II - blood
- Male - blood
- Middle Aged - blood
- Myelodysplastic Syndromes - therapy
- Myeloproliferative Disorders - therapy
- Neopterin - therapy
- Thyroid Gland - immunology
- Time Factors - immunology
- Tumor Necrosis Factor-alpha - analysis
- Find related publications in this database (Keywords)
- THYROID AUTOIMMUNITY
- HYPOTHYROIDISM
- IFN-ALPHA
- MYELOPROLIFERATIVE AND MYELODYSPLASTIC SYNDROMES