Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Thalhammer, F; Gisslinger, H; Chott, A; Haas, O; Etele-Hainz, A; Helbich, T; Kusec, R; Linkesch, W; Simonitsch, I; Strobl, H.
Granulocytic sarcoma of the prostate as the first manifestation of a late relapse of acute myelogenous leukemia.
Ann Hematol. 1994; 68(2):97-99
Doi: 10.1007/BF01715141
(- Case Report)
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- Co-Autor*innen der Med Uni Graz
- Linkesch Werner
- Strobl Herbert
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- Abstract:
- We describe a 68-year-old patient who developed granulocytic sarcoma of the prostate 9 years after complete remission following successful treatment of acute myelogenous leukemia (FAB, M2). PCR analysis of bone marrow samples in first remission and at the time of relapse detected an AML1/ETO rearrangement typical for AMLs with t (8;21). The CD56 antigen was not expressed on the leukemic cells. Systemic chemotherapy led to a short-lasting regression of the tumor, but the patient subsequently developed overt bone marrow relapse and died during chemotherapy. While granulocytic sarcoma as a primary manifestation of AML is well known, as the first manifestation of relapse it appears to be very uncommon.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Core Binding Factor Alpha 2 Subunit -
- DNA-Binding Proteins -
- Gene Rearrangement -
- Humans -
- Leukemia, Myeloid - drug therapy
- Male - drug therapy
- Neoplasm Proteins - genetics
- Neoplasm Recurrence, Local - genetics
- Neoplasms, Second Primary - genetics
- Prostatic Neoplasms - pathology
- Proto-Oncogene Proteins - pathology
- Remission Induction - pathology
- Transcription Factors - pathology
- Find related publications in this database (Keywords)
- GRANULOCYTIC SARCOMA OF THE PROSTATE ACUTE MYELOGENOUS LEUKEMIA
- AML1/ETO REARRANGEMENT