Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Neumeister, P; Hoefler, G; Beham-Schmid, C; Schmidt, H; Apfelbeck, U; Schaider, H; Linkesch, W; Sill, H.
Deletion analysis of the p16 tumor suppressor gene in gastrointestinal mucosa-associated lymphoid tissue lymphomas.
Gastroenterology. 1997; 112(6):1871-1875
Doi: 10.1053%2Fgast.1997.v112.pm9178679
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- Führende Autor*innen der Med Uni Graz
- Neumeister Peter
- Co-Autor*innen der Med Uni Graz
- Apfelbeck Ute
- Beham-Schmid Christine
- Höfler Gerald
- Linkesch Werner
- Schaider Helmut
- Schmidt Helmut
- Sill Heinz
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- Abstract:
- BACKGROUND & AIMS: The molecular mechanisms responsible for initiation and progression of gastrointestinal mucosa-associated lymphoid tissue (MALT) lymphomas are largely unknown. The aim of this study was to analyze the p16 tumor suppressor gene in MALT lymphomas of the stomach and colon. METHODS: Tumor samples were obtained from 28 patients with low-grade (n = 12) and high-grade (n = 14) gastric MALT lymphomas and from 2 patients with colonic MALT lymphomas. DNA was extracted from microdissected areas with at least 80% tumor cells. To detect homozygous p16 deletions, a semiquantitative polymerase chain reaction assay was used, whereby either p16 exon 1 or exon 2 was coamplified with an unrelated sequence as internal control. RESULTS: Homozygous p16 deletions were found in 2 of 14 (14%) cases with high-grade gastric MALT lymphomas. Both patients had Helicobacter pylori-associated gastritis; however, DNA extracted from areas of gastritis showed a normal p16 complement. No deletion was found in any of the low-grade gastric or the colonic MALT lymphoma specimens. CONCLUSIONS: In a subset of gastric MALT lymphomas, homozygous p16 deletions are acquired and may contribute to the transformation from a low-grade to a high-grade malignancy.
- Find related publications in this database (using NLM MeSH Indexing)
- Carrier Proteins - genetics
- Colonic Neoplasms - genetics
- Cyclin-Dependent Kinase Inhibitor p16 - genetics
- Gene Deletion - genetics
- Genes, Tumor Suppressor - genetics
- Humans - genetics
- Lymphoma, Mucosa-Associated Lymphoid Tissue - genetics
- Stomach Neoplasms - genetics