Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Watzke, HH; Linkesch, W; Hay, U.
Giant hemangioma of the liver (Kasabach-Merritt syndrome): successful suppression of intravascular coagulation permitting surgical removal.
J Clin Gastroenterol. 1989; 11(3):347-350
Doi: 10.1097/00004836-198906000-00022
(- Case Report)
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- Co-Autor*innen der Med Uni Graz
- Linkesch Werner
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- Abstract:
- The clinical course of a patient presenting with thrombocytopenia (86 X 10(3)/L) and signs of intravascular coagulation (prothrombin time, 45%; partial thromboplastin time, 49 s; fibrinogen, 40 mg/dl; antithrombin III, 85%; factor X, 73%; plasminogen, 42%) due to a giant hemangioma of the liver (Kasabach-Merritt syndrome) is reported. Treatment with i.v. heparin, fibrinogen, and fresh-frozen plasma led to significant elevation of fibrinogen (156 mg/dl) and antithrombin III (102%) without changing the decreased activities of the procoagulant factors. Similarly, the signs of hyperfibrinolysis persisted (fibrinogen degradation products, 50 micrograms/dl; plasminogen, 43%; alpha-2 antiplasmin, 74%). The hemangioma was completely removed by excision of the left lobe of the liver. Subsequently, all coagulation parameters returned to normal, indicating a complete reversibility of the coagulation disorder.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Disseminated Intravascular Coagulation - etiology
- Female - etiology
- Fibrinogen - therapeutic use
- Hemangioma - complications
- Heparin - therapeutic use
- Humans - therapeutic use
- Liver Neoplasms - complications
- Plasma - complications
- Syndrome - complications