Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Knobler, RM; Pirker, R; Kokoschka, EM; Ludwig, H; Linkesch, W; Micksche, M.
Experimental treatment of chronic lymphocytic leukemia with extracorporeal photochemotherapy. Initial observations.
Blut. 1990; 60(4):215-218
Doi: 10.1007/BF01728786
(- Case Report)
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- Co-Autor*innen der Med Uni Graz
- Linkesch Werner
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- Abstract:
- Based on the encouraging results obtained with extracorporeal photochemotherapy (EP) in the treatment of the exfoliative erythrodermic form of cutaneous T-cell lymphoma (CTCL), leukemic form, as well as other T-cell-mediated diseases we evaluated the therapeutic potential of EP in patients with chronic lymphocytic leukemia (B-CLL). Three patients with B-CLL were treated for a period of 1 year. Two patients showed stabilization of disease, as demonstrated by reduction in their peripheral white blood cell count, with one patient showing lymph-node resolution. A third patient with significant intolerance to previous chemotherapy did not respond within the observed period. No significant side effects of EP were observed. Our observations suggest that EP may have a positive effect on the course of B-CLL in selected patients. Additional clinical trials are warranted to further define the role of EP alone or in combination therapy in the management of B-CLL.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Drug Evaluation -
- Extracorporeal Circulation -
- Humans -
- Leukemia, B-Cell, Chronic - drug therapy
- Methoxsalen - adverse effects
- Middle Aged - adverse effects
- Photochemotherapy - adverse effects
- Pilot Projects - adverse effects
- Ultraviolet Rays - adverse effects