Medizinische Universität Graz - Research portal
Selected Publication:
Sinzinger, H; Linkesch, W; Ludwig, H; Gisslinger, H; O'Grady, J; Peskar, BA.
Impaired conversion of exogenous arachidonic acid by platelets to thromboxane B2 and correction of that deficiency by interferon-alpha.
Prostaglandins. 1990; 40(4):351-360
Doi: 10.1016/0090-6980(90)90100-A
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- Co-authors Med Uni Graz
- Linkesch Werner
- Peskar Bernhard
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- Abstract:
- In the course of an investigation of cyclooxygenase and 12-lipoxygenase activity in platelets of patients with myeloproliferative syndrome receiving treatment with interferon-alpha 2 patients showed unusual results which have not been reported so far. Both patients had thrombocytosis, in one case associated with polycythaemia. In platelets of both patients, a reduced conversion of exogenous 14C arachidonic acid to TXB2 was observed accompanied by a shift in conversion to PGE2 and 12-HETE in one patient and to 12-HETE alone in the other before therapy. These findings were paradoxically associated with evidence of enhanced platelet activation in vivo. Treatment of both patients with interferon-alpha resulted in reversal of the biochemical abnormalities and in clinical remission.
- Find related publications in this database (using NLM MeSH Indexing)
- 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid -
- Aged -
- Arachidonate 12-Lipoxygenase - blood
- Arachidonic Acid - blood
- Arachidonic Acids - blood
- Blood Platelets - metabolism
- Dinoprostone - blood
- Humans - blood
- Hydroxyeicosatetraenoic Acids - blood
- Interferon Type I - therapeutic use
- Male - therapeutic use
- Myeloproliferative Disorders - blood
- Platelet Activation - blood
- Polycythemia Vera - blood
- Prostaglandin-Endoperoxide Synthases - blood
- Thrombocythemia, Hemorrhagic - blood
- Thromboxane B2 - blood