Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Scheithauer, W; Dittrich, C; Kornek, G; Haider, K; Linkesch, W; Gisslinger, H; Depisch, D.
Phase II study of amonafide in advanced breast cancer.
Breast Cancer Res Treat. 1991; 20(1):63-67
Doi: 10.1007/BF01833358
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Linkesch Werner
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- Abstract:
- Twenty-eight patients with advanced breast cancer refractory to prior hormone and/or first-line chemotherapy (with or without anthracycline drugs) were treated with the investigational agent amonafide at a dose of 800 mg/m2 intravenously over 3 hours repeated every 4 weeks. Five objective tumour responses of 5.0 months' median duration were observed in the 20 patients without previous anthracycline exposure, including 1 CR. Leukopenia was the dose-limiting toxicity; though it was generally modest with the 800 mg/m2 amonafide starting dose, an initial dose reduction should be considered in patients with prior radiotherapy and/or bone marrow involvement. Other adverse reactions included nausea/vomiting (53%), phlebitis/erythema along the vein injected (7%), and mild neurotoxic symptoms during the drug administration such as headache, tinnitus, and diaphoresis (21%). Amonafide is an active compound for the treatment of patients with advanced breast cancer and should be considered for further evaluation and incorporation in combination chemotherapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antineoplastic Agents - administration and dosage
- Breast Neoplasms - drug therapy
- Cardiomyopathies - chemically induced
- Drug Evaluation - chemically induced
- Female - chemically induced
- Humans - chemically induced
- Imides - chemically induced
- Infusions, Intravenous - chemically induced
- Isoquinolines - administration and dosage
- Leukopenia - chemically induced
- Middle Aged - chemically induced
- Naphthalimides - chemically induced
- Nausea - chemically induced
- Find related publications in this database (Keywords)
- AMONAFIDE
- ADVANCED BREAST CANCER
- CHEMOTHERAPY