Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Weger, M; Steinbrugger, I; El-Shabrawi, Y; Wegscheider, BJ; Weger, W; Renner, W; Schmut, O; Haas, A.
Haplotype-tagging interleukin-10 promoter polymorphism is associated with reduced risk of retinal artery occlusion.
Mol Vis. 2007; 13(7): 549-552.
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- Führende Autor*innen der Med Uni Graz
- Weger Martin
- Co-Autor*innen der Med Uni Graz
- El-Shabrawi Yosuf
- Haas Anton
- Langner-Wegscheider Beate Julia
- Renner Wilfried
- Schmut Otto
- Steinbrugger Iris
- Weger Wolfgang
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- Abstract:
- PURPOSE: Pro- and anti-inflammatory cytokines, including interleukin 10 (IL-10), play an essential role in atherogenesis. Increased IL-10 production has been found among carriers of the IL10 [TCATA] haplotype, which is formed by five polymorphisms at position -3575, -2763, -1082, -819, and -592 in the promoter region of the IL10 gene. Due to linkage disequilibrium, the presence of the [TCATA] haplotype can be unequivocally determined by analysis of the IL10-592C>A polymorphism. The purpose of the present study was to investigate a hypothesized association between the haplotype-tagging IL10 -592C>A polymorphism and the presence of retinal artery occlusion (RAO). METHODS: The present case-control study was comprised of 194 patients with RAO and 257 normal control subjects. Genotypes of the IL10 -592C>A polymorphism were determined by fluorogenic exonuclease (TaqMan) assay. RESULTS: Carriers of the IL10 -592A-allele, indicating the presence of the IL10 [TCATA] haplotype, were found significantly more often in controls than among patients with RAO (48.6% versus 36.1%; p=0.008). In a logistic regression analysis after adjusting for age, sex, arterial hypertension, diabetes mellitus, hypercholesterolemia, and smoking habits, carriage of the IL10 -592A-allele was associated with an odds ratio of 0.65 (95% CI: 0.44-0.97) for RAO. CONCLUSIONS: Our data suggest that the IL10 [TCATA] haplotype, identified by the presence of the IL10 -592A-allele, may exert a protective effect against RAO.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenine -
- Aged -
- Case-Control Studies -
- Cytosine -
- Female -
- Genotype -
- Haplotypes -
- Heterozygote -
- Humans -
- Interleukin-10 - genetics
- Male - genetics
- Middle Aged - genetics
- Odds Ratio - genetics
- Polymorphism, Genetic - genetics
- Promoter Regions (Genetics) - genetics
- Retinal Artery Occlusion - etiology
- Retrospective Studies - etiology
- Risk - etiology