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Nickel, MK; Loew, TH; Gil, FP.
Aripiprazole in treatment of borderline patients, part II: an 18-month follow-up.
Psychopharmacology (Berl). 2007; 191(4):1023-1026 Doi: 10.1007/s00213-007-0740-0
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Leading authors Med Uni Graz: Nickel-Palczynski Marius
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Abstract:: RATIONALE: Only one controlled trial is known that employed aripiprazole for patients with borderline personality disorder (BPD). This 8-week trial found significant changes on most scales of the symptom checklist (SCL-90-R), Hamilton depression rating scale (HDRS), Hamilton anxiety rating scale (HARS), and on all scales of the state-trait anger expression inventory (STAXI). OBJECTIVES, MATERIALS, AND METHODS: To assess the long-term effectiveness of aripiprazole with multifaceted borderline symptomatology, this 18-month follow-up observation with biannual testing was carried out with the same patients from the previous trial (treated with 15-mg aripiprazole daily, n = 26, 21 female and 5 male patients; previous placebo group, n = 26, 22 female and 4 male patients). RESULTS: According to the intent-to-treat principle, significant changes on all scales of the SCL-90-R, HDRS, HARS, and STAXI were observed in the aripiprazole-treated subjects after 18 months. CONCLUSION: Aripiprazole appears to be an effective and relatively safe agent in the long-term treatment of patients with BPD.
Find related publications in this database (using NLM MeSH Indexing): Antipsychotic Agents - therapeutic use; Borderline Personality Disorder - drug therapy; Female - drug therapy; Follow-Up Studies - drug therapy; Humans - drug therapy; Male - drug therapy; Piperazines - therapeutic use; Psychiatric Status Rating Scales - therapeutic use; Quinolones - therapeutic use; Research Design - therapeutic use; Time Factors - therapeutic use; Treatment Outcome - therapeutic use
Find related publications in this database (Keywords): borderline personality disorder; aripiprazole