Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Cvirn, G; Gallistl, S; Koestenberger, M; Kutschera, J; Ferstl, U; Kellner, J; Jurgens, G; Gries, A.
Effects of beta2-glycoprotein-I on platelet aggregation in cord versus adult whole blood.
PLATELETS. 2007; 18(1): 24-28.
Doi: 10.1080/09537100600800529
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Cvirn Gerhard
- Co-Autor*innen der Med Uni Graz
- Gallistl Siegfried
- Gries Anna
- Jürgens Günther
- Kellner Josef
- Koestenberger Martin
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- Abstract:
- We present a peculiarity of the neonatal hemostatic system that might contribute to establish a procoagulant readiness in neonatal blood by sensitizing neonatal platelets for ADP stimulation. beta2-glycoprotein-I (beta2-GP-I) is a plasma constituent capable of suppressing ADP-induced platelet aggregation. We found significant lower levels of beta2-GP-I in cord vs. adult plasma (120 +/- 27 vs. 180 +/- 37 microg/mL, P<0.001). We demonstrate dose-dependent inhibition of ADP-induced platelet aggregation in cord whole blood (WB) in the presence of increasing amounts of beta2-GP-I, evaluated by means of WB aggregometry employing the impedance method. Particularly, raising the beta2-GP-I concentration in cord WB from neonatal level up to the respective adult value caused significant reduction of amplitude (from 9.5 +/- 2.7 to 2.8 +/- 0.9 Omega, P<0.001) and of slope (from 5.9 +/- 2.4 to 1.89 +/- 0.9 Omega/min, P<0.001), and a significant prolongation of the aggregation time (from 51.8 +/- 22.9 to 110.8 +/- 60.3 s, P<0.001). In conclusion, physiological low levels of beta2-GP-I in cord WB cause enhanced responsiveness of neonatal platelets to ADP stimulation. This mechanism might help to explain the clinically observed well-functioning hemostasis in neonates.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenosine Diphosphate - pharmacology
- Adult - pharmacology
- Age Factors - pharmacology
- Female - pharmacology
- Fetal Blood - physiology
- Hemostasis - physiology
- Humans - physiology
- Infant, Newborn - blood
- Male - blood
- Platelet Aggregation - drug effects
- beta 2-Glycoprotein I - analysis
- Find related publications in this database (Keywords)
- beta 2-glycoprotein-I
- ADP-induced platelet aggregation
- cord whole blood