Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Benesch, M; Sovinz, P; Krammer, B; Lackner, H; Mann, G; Schwinger, W; Gadner, H; Urban, C.
Feasibility and toxicity of intrathecal liposomal cytarabine in 5 children and young adults with refractory neoplastic meningitis.
J Pediatr Hematol Oncol. 2007; 29(4): 222-226.
Doi: 10.1097/MPH.0b013e318041f112
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Benesch Martin
- Co-Autor*innen der Med Uni Graz
- Lackner Herwig
- Ritter-Sovinz Petra
- Schwinger Wolfgang
- Urban Ernst-Christian
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- Abstract:
- Intrathecal (IT) treatment of neoplastic meningitis secondary to relapsed or refractory malignancies is a major challenge for clinicians. We studied feasibility and toxicity of IT administered liposomal cytarabine on a compassionate basis in 5 patients (male, n=4; female, n=1; age at diagnosis 5 to 18 y) with recurrent acute lymphoblastic leukemia (n=3), primary refractory acute myeloid leukemia (n=1), or relapsed medulloblastoma (n=1). All of them had evidence of meningeal involvement as shown by presence of leukemic blasts or solid tumor cells on cytologic examination of cerebrospinal fluid and were refractory to standard central nervous system (CNS) therapy. A total of 33 doses were given. Leukemic blasts or solid tumor cells were cleared from cerebrospinal fluid in all patients. IT liposomal cytarabine was well tolerated in 2 patients, but may have contributed to neurologic side effects in 2 other patients with 1 patient who received high-dose methotrexate 96 hours before IT liposomal cytarabine developing transient encephalopathy. Another patient experienced seizures after 6 well-tolerated doses of IT liposomal cytarabine. In the fifth patient, treatment with IT liposomal cytarabine was not continued after a single dose because of toxic cauda equina syndrome, resulting from previous intensive CNS therapy. If administered simultaneously to other neurotoxic drugs, IT liposomal cytarabine may contribute to neurologic side effects in patients who had received prior intensive CNS-directed therapy. IT liposomal cytarabine should, therefore, be used cautiously, if a patient receives other potentially neurotoxic drugs simultaneously.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Antimetabolites, Antineoplastic - administration and dosage
- Child - administration and dosage
- Child, Preschool - administration and dosage
- Combined Modality Therapy - administration and dosage
- Cytarabine - administration and dosage
- Female - administration and dosage
- Humans - administration and dosage
- Injections, Spinal - administration and dosage
- Liposomes - administration and dosage
- Male - administration and dosage
- Meningeal Neoplasms - cerebrospinal fluid
- Meningitis - therapy
- Find related publications in this database (Keywords)
- children
- intrathecal liposomal cytarabine
- neoplastic meningitis