Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Uderzo, C; Pillon, M; Corti, P; Tridello, G; Tana, F; Zintl, F; Nysom, K; Galambrun, C; Fagioli, F; Varotto, S; Messina, C; Verdeguer, A; Urban, C; Faraci, M; Dini, G; Fedeli, S; Tichelli, A; Rovelli, A; Socié, G.
Impact of cumulative anthracycline dose, preparative regimen and chronic graft-versus-host disease on pulmonary and cardiac function in children 5 years after allogeneic hematopoietic stem cell transplantation: a prospective evaluation on behalf of the EBMT Pediatric Diseases and Late Effects Working Parties.
Bone Marrow Transplant. 2007; 39(11): 667-675.
Doi: 10.1038/sj.bmt.1705652
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- Co-Autor*innen der Med Uni Graz
- Urban Ernst-Christian
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- Abstract:
- This prospective study focused on risk factors and clinical outcome of pulmonary and cardiac late effects after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We prospectively evaluated 162 children by pulmonary function tests (PFTs) and cardiac shortening fraction (SF) before allo-HSCT and yearly up to the 5th year of follow-up. The 5-year cumulative incidence of lung and cardiac impairment was 35 (hazard rate=0.03) and 26% (hazard rate=0.06), respectively. Patients presenting abnormal PFTs and SF at last follow-up were 19 and 13%, respectively, with a median Lansky performance status of 90% (70-100). Chronic graft-versus-host disease (c-GVHD) was the major risk factor for reduced lung function in univariate (P=0.02) and multivariate analysis (P=0.02). Total body irradiation (TBI) alone and TBI together with pre-transplant anthracycline administration were significant risk factors for reduced cardiac function in univariate analysis, only (P=0.04 and 0.004, respectively). In conclusion, our prospective study demonstrates an asymptomatic post-allo-HSCT deterioration of pulmonary and cardiac function in some long-term survivors, who had been transplanted in childhood, and thus emphasizes the need for lifelong cardiopulmonary monitoring and the development of new strategies both to reduce pre-transplant cardiotoxic regimens and to treat more efficiently c-GVHD.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Anthracyclines - administration and dosage
- Cardiac Output - administration and dosage
- Child - administration and dosage
- Child, Preschool - administration and dosage
- Echocardiography - administration and dosage
- Female - administration and dosage
- Graft vs Host Disease - physiopathology
- Heart Diseases - etiology
- Hematopoietic Stem Cell Transplantation - adverse effects
- Humans - adverse effects
- Infant - adverse effects
- Lung Diseases - etiology
- Male - etiology
- Prospective Studies - etiology
- Respiratory Function Tests - etiology
- Transplantation Conditioning - adverse effects
- Transplantation, Homologous - adverse effects
- Treatment Outcome - adverse effects
- Find related publications in this database (Keywords)
- pulmonary
- cardiac late effects
- anthracycline
- transplantation