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Yao, Z; Volgger, A; Helmberg, W; Keller, E; Fan, LA; Chandanayingyong, D; Albert, ED.
Definition of new alleles of MIC-A using sequencing-based typing.
Eur J Immunogenet. 1999; 26(2-3):225-232 Doi: 10.1046%2Fj.1365-2370.1999.00094.x
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Co-authors Med Uni Graz: Helmberg Wolfgang
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Abstract:: We have sequenced exons 2, 3 and 4 of MIC-A in 23 homozygous cell lines, 22 families and 54 unrelated individuals. This has led to the definition of seven polymorphic positions in exon 2, 13 in exon 3 and 12 in exon 4, yielding a total of 33 different MIC-A allelic specificities, of which 16 have not been described before. The newly defined sequences and those of the alleles defined before were entered into a database of the SCORE program (Helmberg et al., 1998, Tissue Antigens, 51, 587) for comprehensive genotyping analysis. In the tested sample, only one genotype present in two individuals gave rise to an ambiguous genotype. If all possible combinations of the 33 alleles are considered, 10 of 636 combinations are ambiguous. The MIC-A exon 2, 3 and 4 polymorphism is characterized by diallelic single base exchanges and by a considerable degree of exon shuffling. The majority of heterozygote positions identified are non-synonymous, i.e. five of seven in exon 2, 13 of 13 in exon 3 and eight of 12 in exon 4, suggesting an important function for the MIC-A polymorphism.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Alleles -; Asian Continental Ancestry Group -; Base Sequence -; Cell Line -; Child -; European Continental Ancestry Group -; Exons -; Female -; Genes, MHC Class I -; HLA-B Antigens - genetics; Heterozygote - genetics; Histocompatibility Antigens Class I - classification; Histocompatibility Testing - classification; Homozygote - classification; Humans - classification; Linkage Disequilibrium - classification; Male - classification; Molecular Sequence Data - classification; Polymerase Chain Reaction - classification; Polymorphism, Genetic - classification; Sequence Analysis, DNA - classification