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SHR Neuro Cancer Cardio Lipid Metab Microb
Stoschitzky, K; Stoschitzky, G; Wonisch, M; Brussee, H.
Differential effects of urapidil and doxazosin on heart rate.
Eur J Clin Pharmacol. 2007; 63(3):259-262
Doi: 10.1007/s00228-006-0256-2
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- Leading authors Med Uni Graz
- Stoschitzky Kurt
- Co-authors Med Uni Graz
- Brussee Helmut
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- Abstract:
- OBJECTIVE: Although alpha-blockers are effective in lowering blood pressure, they may increase heart rate, an unwanted effect that could negatively affect outcome. However, the alpha-blocker urapidil might not increase heart rate due to its additional effect on 5-HT1A receptors. Therefore, we compared the effects of urapidil on heart rate with those of another alpha-blocker, doxazosin. METHODS: We performed a randomised, double-blind, placebo-controlled, cross-over study in 12 healthy males who received single oral doses of 60 mg urapidil, 4 mg doxazosin and placebo. Four hours following drug intake, heart rate and blood pressure were measured at rest and during exercise. RESULTS: Both doxazosin and urapidil decreased blood pressure to the same extent. Compared to placebo, resting heart rate was significantly increased by doxazosin (+25%, P < 0.05) but not by urapidil (+12%, n.s.). Resting heart rate with doxazosin was significantly higher than with urapidil (P < 0.05). Similarly, the rate pressure product (RPP) at rest was increased by doxazosin (+17%, P < 0.05) but not by urapidil (+6%, n.s.). CONCLUSIONS: We conclude that the increase in heart rate caused by urapidil is less pronounced than that with doxazosin, a property that might favour urapidil in the treatment of arterial hypertension. In addition, only doxazosin (but not urapidil) increased the RPP at rest, a finding that might be helpful to explain why this drug was never shown to improve outcome in the treatment of arterial hypertension.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenergic alpha-Antagonists - pharmacology
- Adult - pharmacology
- Blood Pressure - drug effects
- Cross-Over Studies - drug effects
- Double-Blind Method - drug effects
- Doxazosin - pharmacology
- Heart Rate - drug effects
- Humans - drug effects
- Male - drug effects
- Piperazines - pharmacology
- Find related publications in this database (Keywords)
- adrenergic alpha-antagonists
- hypertension
- heart rate
- blood pressure
- rate pressure product