Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Aberer, E; Bergmann, AR; Derler, AM; Schmidt, B.
Course of Borrelia burgdorferi DNA shedding in urine after treatment.
ACTA DERMATO-VENEREOL. 2007; 87(1): 39-42.
Doi: 10.2340/00015555-0172
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- Führende Autor*innen der Med Uni Graz
- Aberer Elisabeth
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- Abstract:
- Diagnosis of Lyme borreliosis by urine polymerase chain reaction (PCR) has been recognized as having better diagnostic sensitivity in patients with erythema migrans than serological methods. We made serial tests with 192 urine specimens from 70 patients with erythema migrans and 60 urine specimens from 21 patients with acrodermatitis chronica atrophicans to evaluate the course of positive urine PCR after antibiotic treatment. Before treatment, urine samples from patients with erythema migrans showed a positive PCR in 27/34 samples (79%), and those from patients with acrodermatitis chronica atrophicans in 7/11 (63%). The specificity of bands was proven by hybridization with GEN-ETI-KTM-DEIA kit in 40/41 samples. Borrelia DNA in urine decreased gradually within the observation period of one year in both patients with erythema migrans and acrodermatitis chronica atrophicans, and persisted without clinical symptoms in 4/45 patients with erythema migrans (8%) after 12 months. Urine PCR can serve as a diagnostic method in early Lyme borreliosis and also in seropositive patients with unclear clinical symptoms.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Anti-Bacterial Agents - therapeutic use
- Borrelia burgdorferi - genetics
- Child - genetics
- DNA, Bacterial - urine
- Erythema Chronicum Migrans - urine
- Female - urine
- Humans - urine
- Lyme Disease - drug therapy
- Male - drug therapy
- Middle Aged - drug therapy
- Polymerase Chain Reaction - drug therapy
- Find related publications in this database (Keywords)
- acrodermathis chronica atrophicans
- erythema migrans
- Lyme borreliosis
- PCR