Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hovorka, R; Chassin, LJ; Wilinska, ME; Canonico, V; Akwi, JA; Federici, MO; Massi-Benedetti, M; Hutzli, I; Zaugg, C; Kaufmann, H; Both, M; Vering, T; Schaller, HC; Schaupp, L; Bodenlenz, M; Pieber, TR.
Closing the loop: the adicol experience.
Diabetes Technol Ther. 2004; 6(3): 307-318.
Doi: 10.1089/152091504774197990
PubMed
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- Co-authors Med Uni Graz
- Pieber Thomas
- Schaupp Lukas
- Weiss Manfred
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- Abstract:
- The objective of the project Advanced Insulin Infusion using a Control Loop (ADICOL) was to develop a treatment system that continuously measures and controls the glucose concentration in subjects with type 1 diabetes. The modular concept of the ADICOL's extracorporeal artificial pancreas consisted of a minimally invasive subcutaneous glucose system, a handheld PocketPC computer, and an insulin pump (D-Tron, Disetronic, Burgdorf, Switzerland) delivering subcutaneously insulin lispro. The present paper describes a subset of ADICOL activities focusing on the development of a glucose controller for semi-closed-loop control, an in silico testing environment, clinical testing, and system integration. An incremental approach was adopted to evaluate experimentally a model predictive glucose controller. A feasibility study was followed by efficacy studies of increasing complexity. The ADICOL project demonstrated feasibility of a semi-closed-loop glucose control during fasting and fed conditions with a wearable, modular extracorporeal artificial pancreas.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Glucose - analysis
- Diabetes Mellitus, Type 1 - blood
- Equipment Design - blood
- Humans - blood
- Insulin Infusion Systems - blood
- Monitoring, Ambulatory - instrumentation