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Selected Publication:
Sakotnik, A; Liebmann, PM; Stoschitzky, K; Lercher, P; Schauenstein, K; Klein, W; Eber, B.
Decreased melatonin synthesis in patients with coronary artery disease.
Eur Heart J. 1999; 20(18):1314-1317
Doi: 10.1053/euhj.1999.1527
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- Leading authors Med Uni Graz
- Amegah-Sakotnik Andrea
- Liebmann-Holzmann Peter
- Co-authors Med Uni Graz
- Lercher Peter
- Schauenstein Konrad
- Stoschitzky Kurt
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- Abstract:
- Aims: Decreased night-time plasma levels of melatonin were recently reported in patients with coronary artery disease, and it was postulated that melatonin production may be impaired, due to a lack of synthesizing enzymes. However, since artefacts possibly influencing the release pattern were not taken into account, this interpretation was strongly criticized. We therefore carefully investigated night-time melatonin production in patients with coronary artery disease using an appropriate experimental approach. Furthermore, we examined the effect of beta-blockers, a frequently used drug in coronary artery disease therapy. Methods and Results: Forty-eight male patients with angiographically documented severe coronary artery disease, 24 of them taking beta-blockers daily in therapeutic dosages, were included. Eighteen age-matched men, with no evidence of coronary sclerosis, served as controls. To determine melatonin production, 6-sulfatoxymelatonin (aMT6s) was measured radioimmunologically from overnight urine. Urinary aMT6s concentration was significantly decreased in patients, and beta-blocker treatment did not further suppress melatonin production. Conclusions: The data obtained using this investigative approach provide clearcut evidence that melatonin production in patients with coronary artery disease is decreased. Whether a decreased melatonin level may be a predisposing factor for coronary artery disease, or whether the occurrence of coronary artery disease decreases melatonin synthesis remains to be determined.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenergic beta-Antagonists - therapeutic use
- Adult - therapeutic use
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- Analysis of Variance - therapeutic use
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- Circadian Rhythm - therapeutic use
- Coronary Artery Disease - drug therapy
- Humans - drug therapy
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- Find related publications in this database (Keywords)
- Melatonin
- Coronary Artery Disease
- Antioxidants
- Atherosclerosis
- Low Density Lipoprotein