Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Jörg, B; Kerl, H; Thiers, BH; Bröcker, EB; Burg, G.
Therapeutic approaches in cutaneous lymphoma.
Dermatol Clin. 1994; 12(2):433-441
Doi: 10.1016/S0733-8635(18)30191-8
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- Co-Autor*innen der Med Uni Graz
- Kerl Helmut
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- Abstract:
- Standard therapy of the CTCL MF and SS consists of topical glucocorticosteroids, PUVA, topical chemotherapy, and total skin electron beam irradiation in stages Ia and IIa; local radiation or total skin electron beam irradiation in stage IIb; and systemic chemotherapy in stages III and IV. The experimental treatment modalities, interferon-alpha and retinoids, especially arotinoid, are most effective in early stages of CTCL; in advanced stages, the effectiveness can be increased by combination regimens. Up to now, the most promising results are obtained by combination therapy of interferon and PUVA. When serotherapy is considered as a therapeutic alternative for patients in stage IIb to IVb, the benefit/risk ratio must be carefully analyzed. Anti-thymocyte-globulin and monoclonal antibodies, either alone or conjugated to radioisotopes or toxin, have shown some therapeutic effect but are still under investigation. Extracorporal photopheresis is well established in erythrodermic patients. Initial reports also have shown encouraging results with this treatment for stage Ib and in combination with methotrexate or interferon. Hexadecylphosphocholine, a new, well-tolerated topical agent, induced a remission rate of 50%, with 25% complete remission in CTCL patients of stage Ia to IIb.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents - therapeutic use
- Combined Modality Therapy - therapeutic use
- Humans - therapeutic use
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- Mechlorethamine - therapeutic use
- PUVA Therapy - therapeutic use
- Radiotherapy - therapeutic use
- Retinoids - therapeutic use
- Skin Neoplasms - therapy