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SHR Neuro Cancer Cardio Lipid Metab Microb
Wackernagel, A; Legat, FJ; Hofer, A; Quehenberger, F; Kerl, H; Wolf, P.
Psoralen plus UVA vs. UVB-311 nm for the treatment of lichen planus.
Photodermatol Photoimmunol Photomed. 2007; 23(1):15-19
Doi: 10.1111/j.1600-0781.2007.00261.x
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Gruber-Wackernagel Alexandra
- Wolf Peter
- Co-authors Med Uni Graz
- Hofer Angelika
- Kerl Helmut
- Legat Franz
- Quehenberger Franz
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- Abstract:
- The purpose of this study was to evaluate and compare the short- and long-term therapeutic efficacy of psoralen plus UVA (PUVA) vs. UVB-311 nm in the treatment of patients with disseminated lichen planus. A computerized data bank search and chart review revealed that data from a total of 28 patients, including 15 patients [11 women, four men; mean age 47 years (range, 16-65 years)] treated between 1998 and 2004 with PUVA and 13 patients [10 women, three men; mean age 51 years (range, 19-69 years)] treated with UVB-311 nm, were available at our institution for retrospective analysis. All 15 patients (100%) treated with oral PUVA had a complete [n=10 (67%)] or partial [n=5 (33%)] clinical response, whereas 10 of 13 patients (77%) treated with UVB-311 nm showed complete [n=4 (31%)] or partial [n=6 (46%)] clinical response. Statistical analysis revealed that the initial response to PUVA was superior to that of UVB-311 nm (P=0.0426; Wilcoxon's exact test). There were no statistically significant differences between the PUVA- and UVB-311 nm-treated patient groups with regard to mean therapy duration (10.5 vs. 8.2 weeks; P=0.1107; unpaired, two-tailed Student's t test) or mean number of treatment exposures (25.9 vs. 22.5; P=0.1775). After a mean follow-up period of 20.5 months (range, 2-49 months) and 35.7 months (range, 3-60 months), respectively, disease recurrence or deterioration was observed in seven of 15 PUVA-treated patients (47%) and three of 10 UVB-311 nm-treated patients (30%). Kaplan-Meier lifetime table analysis revealed no statistically significant difference between the 2 treatment groups in terms of sustained overall (i.e., partial and complete) clinical response rate (P=0.8593; log-rank test). Even though oral PUVA produces a better initial clinical response rate, both oral PUVA and UVB-311 nm are effective treatments for lichen planus that produce similar long-term outcomes.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Female -
- Ficusin - therapeutic use
- Humans -
- Lichen Planus - radiotherapy
- Male -
- Middle Aged -
- Photosensitizing Agents - therapeutic use
- Retrospective Studies -
- Statistics, Nonparametric -
- Treatment Outcome -
- Ultraviolet Therapy - methods
- Find related publications in this database (Keywords)
- lichen planus
- psoralen plus UVA (PUVA)
- UVB-311 nm