Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Siekmeier, R; März, W; Gross, W.
Precipitation of LDL with sulfated polyanions: three methods compared.
Clin Chim Acta. 1988; 177(3):221-230
Doi: 10.1016/0009-8981(88)90066-6
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- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- Three precipitation methods for the determination of low density lipoproteins have been evaluated. In n = 113 normolipidemic samples mean LDL-cholesterol levels have been 2.90 mmol/l, 2.77 mmol/l, 3.21 mmol/l after precipitation with heparin, dextran sulfate, and polyvinylsulfate, respectively. As compared to a combined ultracentrifugation and precipitation reference procedure (mean 3.22 mmol/l) two precipitation methods tend to underrate LDL-cholesterol. Elevated plasma triglycerides may interfere with the precipitation of LDL. The clinical relevance of the precipitation procedures has been studied by discriminant analysis in n = 28 consecutive patients admitted for coronary bypass operation and n = 28 controls. The data suggest that, statistically, the determination of LDL-cholesterol with either precipitation method only provides redundant information as in relation to the Friedewald approximation for LDL-cholesterol. Immunologically determined apolipoprotein B proved a better predictor for group separation than either precipitation method.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Coronary Disease - blood
- Dextran Sulfate - blood
- Dextrans - blood
- Female - blood
- Heparin - blood
- Humans - blood
- Indicators and Reagents - blood
- Lipoproteins, LDL - blood
- Male - blood
- Middle Aged - blood
- Polyvinyls - blood
- Precipitation - blood
- Ultracentrifugation - blood