Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Grützmacher, P; März, W; Peschke, B; Gross, W; Schoeppe, W.
Lipoproteins and apolipoproteins during the progression of chronic renal disease.
Nephron. 1988; 50(2):103-111
Doi: 10.1159/000185138
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-Autor*innen der Med Uni Graz
- März Winfried
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The association between lipoprotein and apolipoprotein levels and the degree of renal failure was investigated in 72 conservatively treated patients with chronic renal disease. The progression of renal insufficiency was attended by marked increases in total triglycerides, and very-low-density (VLDL), low-density (LDL) and high-density (HDL) lipoprotein triglycerides. Total cholesterol was slightly elevated due to a rise in VLDL cholesterol. There was no change in LDL cholesterol, whereas HDL cholesterol decreased. Apo C-II and C-III showed distinct increases, their mass ratio decreasing only insignificantly. Apo B and A-I were unaffected by the degree of renal insufficiency, whereas apo A-II decreased. The findings reflect compositional changes within HDL and the accumulation to triglyceride-rich lipoproteins in chronic renal disease. The alterations in the plasma lipoprotein pattern were demonstrable even in early stages of renal failure and, therefore, may bear a serious risk for the acceleration of atherosclerosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Apolipoproteins - blood
- Cholesterol - blood
- Creatinine - metabolism
- Female - metabolism
- Humans - metabolism
- Kidney Failure, Chronic - blood
- Lipoproteins - blood
- Male - blood
- Middle Aged - blood
- Triglycerides - blood