Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Russ, AP; Ruzicka, V; Maerz, W; Appelhans, H; Gross, W.
Amplification and direct sequencing of a cDNA encoding human cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase.
Biochim Biophys Acta. 1992; 1132(3):329-331
Doi: 10.1016/0167-4781(92)90172-V
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- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- Cytosolic 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) synthase (E.C. 4.1.3.5) is a highly regulated enzyme involved in isoprenoid biosynthesis and therefore a potential target for cholesterol-lowering drugs. Up to now, primary structure data have only been available for chicken, rat and hamster HMG-CoA synthase. Using in vitro amplification and direct sequencing, we have determined the nucleotide sequence of the coding region of the human cytosolic 3-hydroxy-3-methylglutaryl CoA synthase cDNA.
- Find related publications in this database (using NLM MeSH Indexing)
- Amino Acid Sequence -
- Base Sequence -
- DNA -
- Humans -
- Hydroxymethylglutaryl-CoA Synthase - genetics
- Molecular Sequence Data - genetics
- Polymerase Chain Reaction - genetics
- Find related publications in this database (Keywords)
- 3-HYDROXY-3-METHYLGLUTARYL COA (HMG-COA) SYNTHASE CDNA
- CHOLESTEROL BIOSYNTHESIS
- ISOPRENOID BIOSYNTHESIS
- (HUMAN)