Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kuhl, H; März, W; Jung-Hoffmann, C; Weber, J; Siekmeier, R; Gross, W.
Effect on lipid metabolism of a biphasic desogestrel-containing oral contraceptive: divergent changes in apolipoprotein B and E and transitory decrease in Lp(a) levels.
Contraception. 1993; 47(1):69-83
Doi: 10.1016/0010-7824(93)90110-S
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- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- The effect of a low dose biphasic oral contraceptive containing 40 micrograms ethinylestradiol + 25 micrograms desogestrel (7 tablets) and 30 micrograms ethinylestradiol + 125 micrograms desogestrel (15 tablets) on lipid metabolism was investigated in 19 women during 6 cycles of treatment and compared to the values of the pre- and post-treatment cycle. During treatment, all components of HDL increased reversibly by 10 to 30%. The levels of total cholesterol (CH), LDL-CH and IDL-CH rose only slightly, while those of total triglycerides (TG), VLDL-TG and LDL-TG rose continuously by more than 100% until the 6th cycle. At the same time, plasma levels of VLDL-CH increased by 60% and of apolipoprotein B by 20%. Contrary to this, apolipoprotein E decreased by 25% during treatment, and Lp(a) was transitorily reduced during the 3rd cycle. After termination of intake, total CH, LDL-CH, IDL-CH and apolipoprotein B remained elevated, while total TG, VLDL-TG, VLDL-CH and LDL-TG decreased significantly, but were still elevated during the post-treatment cycle. The levels of apolipoprotein E returned to pre-treatment values. The results indicate a marked preponderance of the effect of the estrogen component. The rise in TG and VLDL synthesis seems to be outweighed by an enhanced removal of apolipoprotein E-containing remnants which might offer protection from the development of atherosclerosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Apolipoproteins B - blood
- Apolipoproteins E - blood
- Cholesterol - blood
- Contraceptives, Oral, Sequential - pharmacology
- Desogestrel - pharmacology
- Ethinyl Estradiol - pharmacology
- Female - pharmacology
- Humans - pharmacology
- Lipid Metabolism - pharmacology
- Lipoprotein(a) - blood
- Triglycerides - blood