Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
März, W; Feussner, G; Siekmeier, R; Donnerhak, B; Schaaf, L; Ruzicka, V; Gross, W.
Apolipoprotein E to B ratio: a marker for type III hyperlipoproteinaemia.
Eur J Clin Chem Clin Biochem. 1993; 31(11):743-747
Doi: 10.1515/cclm.1993.31.11.743
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- Führende Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- Apolipoproteins B and E were determined in 40 patients with type III hyperlipoproteinaemia (familial dysbetalipoproteinaemia) and in 48 patients with other types of hyperlipoproteinaemia matched for cholesterol and triacylglycerols. In type III patients, apolipoprotein E was increased and apolipoprotein B was lower than in other types of hyperlipoproteinaemia. The apolipoprotein E to apolipoprotein B ratio almost completely discriminated between type III and other types of hyperlipoproteinaemia. Assuming a cut-off value of 0.09 for the apolipoprotein E to apolipoprotein B ratio, diagnostic sensitivity was 95% and specificity was 88%. It is concluded that the apolipoprotein E to apolipoprotein B ratio represents the first-line screening quantity of choice for the identification of patients with type III hyperlipoproteinaemia in the clinical laboratory.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Apolipoproteins B - analysis
- Apolipoproteins E - analysis
- Biological Markers - blood
- Female - blood
- Humans - blood
- Hyperlipoproteinemia Type III - blood
- Male - blood
- Middle Aged - blood
- Sensitivity and Specificity - blood